Vorescore--fold recognition improved by rescoring of protein structure models.

ABSTRACT:

Summary

The identification of good protein structure models and their appropriate ranking is a crucial problem in structure prediction and fold recognition. For many alignment methods, rescoring of alignment-induced models using structural information can improve the separation of useful and less useful models as compared with the alignment score. Vorescore, a template-based protein structure model rescoring system is introduced. The method scores the model structure against the template used for the modeling using Vorolign. The method works on models from different alignment methods and incorporates both knowledge from the prediction method and the rescoring.

Results

The performance of Vorescore is evaluated in a large-scale and difficult protein structure prediction contex

SUBMITTER: Csaba G 

PROVIDER: S-EPMC2935407 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature