BioNetCAD: design, simulation and experimental validation of synthetic biochemical networks.

ABSTRACT:

Motivation

Synthetic biology studies how to design and construct biological systems with functions that do not exist in nature. Biochemical networks, although easier to control, have been used less frequently than genetic networks as a base to build a synthetic system. To date, no clear engineering principles exist to design such cell-free biochemical networks.

Results

We describe a methodology for the construction of synthetic biochemical networks based on three main steps: design, simulation and experimental validation. We developed BioNetCAD to help users to go through these steps. BioNetCAD allows designing abstract networks that can be implemented thanks to CompuBioTicDB, a database of parts for synthetic biology. BioNetCAD enables also simulations with the HSim softwar

SUBMITTER: Rialle S 

PROVIDER: S-EPMC2935418 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature