Parsimony and likelihood reconstruction of human segmental duplications.

ABSTRACT:

Motivation

Segmental duplications > 1 kb in length with >or= 90% sequence identity between copies comprise nearly 5% of the human genome. They are frequently found in large, contiguous regions known as duplication blocks that can contain mosaic patterns of thousands of segmental duplications. Reconstructing the evolutionary history of these complex genomic regions is a non-trivial, but important task.

Results

We introduce parsimony and likelihood techniques to analyze the evolutionary relationships between duplication blocks. Both techniques rely on a generic model of duplication in which long, contiguous substrings are copied and reinserted over large physical distances, allowing for a duplication block to be constructed by aggregating substrings of other blocks. For the li

SUBMITTER: Kahn CL 

PROVIDER: S-EPMC2935423 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature