Discriminatory power of RNA family models.

ABSTRACT:

Motivation

RNA family models group nucleotide sequences that share a common biological function. These models can be used to find new sequences belonging to the same family. To succeed in this task, a model needs to exhibit high sensitivity as well as high specificity. As model construction is guided by a manual process, a number of problems can occur, such as the introduction of more than one model for the same family or poorly constructed models. We explore the Rfam database to discover such problems.

Results

Our main contribution is in the definition of the discriminatory power of RNA family models, together with a first algorithm for its computation. In addition, we present calculations across the whole Rfam database that show several families lacking high specificity wh

SUBMITTER: Honer zu Siederdissen C 

PROVIDER: S-EPMC2935435 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature