Ontology highlight
ABSTRACT:
SUBMITTER: Sun W
PROVIDER: S-EPMC2935461 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Sun Wei W Wright Fred A FA Tang Zhengzheng Z Nordgard Silje H SH Van Loo Peter P Yu Tianwei T Kristensen Vessela N VN Perou Charles M CM
Nucleic acids research 20090706 16
We propose a statistical framework, named genoCN, to simultaneously dissect copy number states and genotypes using high-density SNP (single nucleotide polymorphism) arrays. There are at least two types of genomic DNA copy number differences: copy number variations (CNVs) and copy number aberrations (CNAs). While CNVs are naturally occurring and inheritable, CNAs are acquired somatic alterations most often observed in tumor tissues only. CNVs tend to be short and more sparsely located in the geno ...[more]