Association of meat and fat intake with liver disease and hepatocellular carcinoma in the NIH-AARP cohort.

ABSTRACT:

Background

Several plausible mechanisms, including fat, iron, heterocyclic amines, and N-nitroso compounds, link meat intake with chronic liver disease (CLD) and hepatocellular carcinoma (HCC). Few studies have investigated these associations.

Methods

We prospectively examined the relationship between meat and associated exposures with CLD mortality (n = 551; not including HCC) and HCC incidence (n = 338) in 495 006 men and women of the National Institutes of Health-AARP Diet and Health Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the fifth (Q5) vs the first (Q1) quintile were estimated from multivariable adjusted Cox proportional hazards regression models. All tests of statistical significance were two-sided.

Results

We found inverse associations

SUBMITTER: Freedman ND 

PROVIDER: S-EPMC2935477 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature