Modulation of gene expression in endothelial cells by hyperlipaemic postprandial serum from healthy volunteers.

ABSTRACT:

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A single high-fat challenge induces plasmatic pro-inflammatory and pro-oxidative responses in the postprandial state, even in healthy men. This period is also associated with vascular endothelial dysfunction, which is an early event in the development of cardiovascular diseases. However, knowledge about the mechanisms involved in postprandial hyperlipaemia-induced endothelial dysfunction is sparse. An objective of our study was to characterize the behaviour and gene expression of vascular endothelial cells exposed to postprandial hyperlipaemic sera. Human umbilical vein endothelial cells (HUVECs) were cultured in media containing 10% serum from healthy men withdrawn either before or 4 h after a high-fat challenge. Endothelial cell proliferation, adhesion and migration we

SUBMITTER: Dejeans N 

PROVIDER: S-EPMC2935529 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature