The localization and density of immune cells in primary tumors of human metastatic colorectal cancer shows an association with response to chemotherapy.

ABSTRACT: In situ immunohistochemical staining of tumor-infiltrating immune cells in large cohorts of human colorectal cancers has recently supported the hypothesis that the adaptive immune response influences the behavior of human tumors. Tumor-infiltrating immune cells therefore represent a valuable prognostic marker for patients with colorectal cancer, with a high density of immune cells being associated with a good outcome independently of other established prognostic markers. The aim of the present study was to investigate the correlation between infiltrates of immune cells, in either the primary tumor or (where available) the corresponding liver metastases, with the response to chemotherapy in patients with metastatic colorectal cancer. The analysis consisted of 32 samples from 22 patients wit

SUBMITTER: Halama N 

PROVIDER: S-EPMC2935770 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature