Silver-catalyzed late-stage fluorination.

ABSTRACT: Carbon-fluorine bond formation by transition metal catalysis is difficult, and only a few methods for the synthesis of aryl fluorides have been developed. All reported transition-metal-catalyzed fluorination reactions for the synthesis of functionalized arenes are based on palladium. Here we present silver catalysis for carbon-fluorine bond formation. Our report is the first example of the use of the transition metal silver to form carbon-heteroatom bonds by cross-coupling catalysis. The functional group tolerance and substrate scope presented here have not been demonstrated for any other fluorination reaction to date.

SUBMITTER: Tang P 

PROVIDER: S-EPMC2935811 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature