Ischemic preconditioning regulates expression of microRNAs and a predicted target, MeCP2, in mouse cortex.

ABSTRACT: Preconditioning describes the ischemic stimulus that triggers an endogenous, neuroprotective response that protects the brain during a subsequent severe ischemic injury, a phenomenon known as 'tolerance'. Ischemic tolerance requires new protein synthesis, leads to genomic reprogramming of the brain's response to subsequent ischemia, and is transient. MicroRNAs (miRNAs) regulate posttranscriptional gene expression by exerting direct effects on messenger RNA (mRNA) translation. We examined miRNA expression in mouse cortex in response to preconditioning, ischemic injury, and tolerance. The results of our microarray analysis revealed that miRNA expression is consistently altered within each group, but that preconditioning was the foremost regulator of miRNAs. Our bioinformatic analysis results

SUBMITTER: Lusardi TA 

PROVIDER: S-EPMC2935903 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature