Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma.

ABSTRACT:

Background

A subset of children with asthma respond better to leukotriene receptor antagonists than to inhaled corticosteroids. Information is needed to identify children with these preferential responses.

Objective

We sought to determine whether the ratio of urinary leukotriene E(4) (LTE(4)) to fractional exhaled nitric oxide (FE(NO)) delineates children with preferential responsiveness to montelukast compared with fluticasone propionate (FP) therapy.

Methods

Data from 318 children with mild-to-moderate asthma enrolled in 2 National Heart, Lung, and Blood Institute Childhood Asthma Research and Education Network studies (Characterizing the Response to a Leukotriene Receptor Antagonist and an Inhaled Corticosteroid [CLIC] and the Pediatric Asthma Controller Trial [PAC

SUBMITTER: Rabinovitch N 

PROVIDER: S-EPMC2935914 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature