Curating the innate immunity interactome.

ABSTRACT:

Background

The innate immune response is the first line of defence against invading pathogens and is regulated by complex signalling and transcriptional networks. Systems biology approaches promise to shed new light on the regulation of innate immunity through the analysis and modelling of these networks. A key initial step in this process is the contextual cataloguing of the components of this system and the molecular interactions that comprise these networks. InnateDB (http://www.innatedb.com) is a molecular interaction and pathway database developed to facilitate systems-level analyses of innate immunity.

Results

Here, we describe the InnateDB curation project, which is manually annotating the human and mouse innate immunity interactome in rich contextual detail, and pres

SUBMITTER: Lynn DJ 

PROVIDER: S-EPMC2936296 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature