What happened after the initial global spread of pandemic human influenza virus A (H1N1)? A population genetics approach.

ABSTRACT: Viral population evolution dynamics of influenza A is crucial for surveillance and control. In this paper we analyzed viral genetic features during the recent pandemic caused by the new influenza human virus A H1N1, using a conventional population genetics approach based on 4689 hemagglutinin (HA) and neuraminidase (NA) sequences available in GenBank submitted between March and December of 2009. This analysis showed several relevant aspects: a) a scarce initial genetic variability within the viral isolates from some countries that increased along 2009 when influenza was dispersed around the world; b) a worldwide virus polarized behavior identified when comparing paired countries, low differentiation and high gene flow were found in some pairs and high differentiation and moderate or scarce

SUBMITTER: Martinez-Hernandez F 

PROVIDER: S-EPMC2936310 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature