Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese.

ABSTRACT:

Background

Recent studies identified an increased risk of prostate cancer (PCa) in Caucasian men harboring polymorphisms of genes involved in innate immunity and inflammation. This study was designed to assess whether single nucleotide polymorphisms in the IL-10 promoter play a role in predisposing individuals to PCa in a Chinese population.

Methods

We genotyped three SNPs of the IL-10 promoter (-1082A/G, -819T/C and -592A/C) using polymerase chain reaction-restriction fragment length polymorphism analysis in 262 subjects with PCa and 270 age-matched healthy controls. Odds ratio and 95% confidence interval were determined by logistic regression for the associations between IL-10 genotypes and haplotypes with the risk of PCa and advanced PCa grade.

Results

No significa

SUBMITTER: Liu J 

PROVIDER: S-EPMC2936329 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature