A Pleiotrophin C-terminus peptide induces anti-cancer effects through RPTPβ/ζ.

ABSTRACT:

Background

Pleiotrophin, also known as HARP (Heparin Affin Regulatory Peptide) is a growth factor expressed in various tissues and cell lines. Pleiotrophin participates in multiple biological actions including the induction of cellular proliferation, migration and angiogenesis, and is involved in carcinogenesis. Recently, we identified and characterized several pleiotrophin proteolytic fragments with biological activities similar or opposite to that of pleiotrophin. Here, we investigated the biological actions of P(122-131), a synthetic peptide corresponding to the carboxy terminal region of this growth factor.

Results

Our results show that P(122-131) inhibits in vitro adhesion, anchorage-independent proliferation, and migration of DU145 and LNCaP cells, which express pleiot

SUBMITTER: Diamantopoulou Z 

PROVIDER: S-EPMC2936342 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature