Oxidant-NO dependent gene regulation in dogs with type I diabetes: impact on cardiac function and metabolism.

ABSTRACT:

Background

The mechanisms responsible for the cardiovascular mortality in type I diabetes (DM) have not been defined completely. We have shown in conscious dogs with DM that: 1) baseline coronary blood flow (CBF) was significantly decreased, 2) endothelium-dependent (ACh) coronary vasodilation was impaired, and 3) reflex cholinergic NO-dependent coronary vasodilation was selectively depressed. The most likely mechanism responsible for the depressed reflex cholinergic NO-dependent coronary vasodilation was the decreased bioactivity of NO from the vascular endothelium. The goal of this study was to investigate changes in cardiac gene expression in a canine model of alloxan-induced type 1 diabetes.

Methods

Mongrel dogs were chronically instrumented and the dogs were divided int

SUBMITTER: Ojaimi C 

PROVIDER: S-EPMC2936363 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature