CircuitsDB: a database of mixed microRNA/transcription factor feed-forward regulatory circuits in human and mouse.

ABSTRACT:

Background

Transcription Factors (TFs) and microRNAs (miRNAs) are key players for gene expression regulation in higher eukaryotes. In the last years, a large amount of bioinformatic studies were devoted to the elucidation of transcriptional and post-transcriptional (mostly miRNA-mediated) regulatory interactions, but little is known about the interplay between them.

Description

Here we describe a dynamic web-accessible database, CircuitsDB, supporting a genome-wide transcriptional and post-transcriptional regulatory network integration, for the human and mouse genomes, based on a bioinformatic sequence-analysis approach. In particular, CircuitsDB is currently focused on the study of mixed miRNA/TF Feed-Forward regulatory Loops (FFLs), i.e. elementary circuits in which a mast

SUBMITTER: Friard O 

PROVIDER: S-EPMC2936401 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature