Cytoplasmic inheritance of transplantation antigens in animals produced by nuclear transfer.

ABSTRACT:

Background

Nuclear transfer has been used as a means of selectively modifying the mammalian genome. One possible consequence of this technology is that the oocytes used in nuclear transfer may provide additional antigens by cytoplasmic inheritance of maternally derived, mitochondrial DNA (mtDNA). These studies examine the potential consequences of such inheritance in a large animal transplantation model.

Methods

Renal transplants were performed between major histocompatibility complex (MHC)-identical animals differing only in the source of their maternally derived cytoplasmic DNA, using a protocol, which uniformly leads to tolerance within standard MHC-inbred lines. In an attempt to correlate transplant results with a putative marker for disparities in cytoplasmically inheri

SUBMITTER: Hanekamp JS 

PROVIDER: S-EPMC2936509 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature