Steric shielding of surface epitopes and impaired immune recognition induced by the ebola virus glycoprotein.

ABSTRACT: Many viruses alter expression of proteins on the surface of infected cells including molecules important for immune recognition, such as the major histocompatibility complex (MHC) class I and II molecules. Virus-induced downregulation of surface proteins has been observed to occur by a variety of mechanisms including impaired transcription, blocks to synthesis, and increased turnover. Viral infection or transient expression of the Ebola virus (EBOV) glycoprotein (GP) was previously shown to result in loss of staining of various host cell surface proteins including MHC1 and β1 integrin; however, the mechanism responsible for this effect has not been delineated. In the present study we demonstrate that EBOV GP does not decrease surface levels of β1 integrin or MHC1, but rather impedes recogn

SUBMITTER: Francica JR 

PROVIDER: S-EPMC2936550 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature