Cortico-striatal connections predict control over speed and accuracy in perceptual decision making.

ABSTRACT: When people make decisions they often face opposing demands for response speed and response accuracy, a process likely mediated by response thresholds. According to the striatal hypothesis, people decrease response thresholds by increasing activation from cortex to striatum, releasing the brain from inhibition. According to the STN hypothesis, people decrease response thresholds by decreasing activation from cortex to subthalamic nucleus (STN); a decrease in STN activity is likewise thought to release the brain from inhibition and result in responses that are fast but error-prone. To test these hypotheses-both of which may be true-we conducted two experiments on perceptual decision making in which we used cues to vary the demands for speed vs. accuracy. In both experiments, behavioral data

SUBMITTER: Forstmann BU 

PROVIDER: S-EPMC2936628 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature