Evaluation of breast cancer susceptibility loci in Chinese women.

ABSTRACT:

Background

Recent genome-wide association studies (GWAS), mostly conducted among women of European ancestry, have identified 16 single-nucleotide polymorphisms (SNP) associated with breast cancer.

Methods

We evaluated these SNPs with the risk of breast cancer and further by estrogen receptor status in a population-based study of 6,498 cases and 3,999 controls in Chinese women. We also searched for novel genetic risk variants in four loci, 2q35, 5p12/MRPS30, 8q24.21, and 17q23.2/COX11, in a two-stage study. In stage I, 868 SNPs were analyzed in 2,073 cases and 2,084 controls. In stage II, 58 SNPs selected from stage I were evaluated, including 4,425 cases and 1,915 controls.

Results

Statistically significant associations (P < 0.05) were observed for eight GWAS-identifi

SUBMITTER: Long J 

PROVIDER: S-EPMC2936687 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature