Functional connectivity in blood oxygenation level-dependent and cerebral blood volume-weighted resting state functional magnetic resonance imaging in the rat brain.

ABSTRACT:

Purpose

To directly compare functional connectivity and spatiotemporal dynamics acquired with blood oxygenation level-dependent (BOLD) and cerebral blood volume (CBV)-weighted functional magnetic resonance imaging (fMRI) in anesthetized rats.

Materials and methods

A series of BOLD images were acquired in 10 rats followed by CBV-weighted images created by injection of ultrasmall iron oxide particles. Functional connectivity, spectral information, and spatiotemporal dynamics were compared for the BOLD and CBV-weighted resting state scans.

Results

BOLD scans exhibited higher cross-correlation values compared to CBV-weighted scans, but the spatial patterns of correlation were similar. The BOLD spectrum contains power evenly distributed throughout the low-frequency range w

SUBMITTER: Magnuson M 

PROVIDER: S-EPMC2936716 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature