Associations between genetic variations in the FURIN gene and hypertension.

ABSTRACT:

Background

Hypertension is a complex disease influenced by multiple genetic and environmental factors. The Kazakh ethnic group is characterized by a relatively high prevalence of hypertension. Previous research indicates that the FURIN gene may play a pivotal role in the renin-angiotensin system and maintaining the sodium-electrolyte balance. Because these systems influence blood pressure regulation, we considered FURIN as a candidate gene for hypertension. The purpose of this study was to systematically investigate the association between genetic variations in the FURIN gene and essential hypertension in a Xinjiang Kazakh population.

Methods

We sequenced all exons and the promoter regions of the FURIN gene in 94 hypertensive individuals to identify genetic variations associ

SUBMITTER: Li N 

PROVIDER: S-EPMC2936893 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature