Myosin-dependent targeting of transmembrane proteins to neuronal dendrites.

ABSTRACT: The distinct electrical properties of axonal and dendritic membranes are largely a result of specific transport of vesicle-bound membrane proteins to each compartment. How this specificity arises is unclear because kinesin motors that transport vesicles cannot autonomously distinguish dendritically projecting microtubules from those projecting axonally. We hypothesized that interaction with a second motor might enable vesicles containing dendritic proteins to preferentially associate with dendritically projecting microtubules and avoid those that project to the axon. Here we show that in rat cortical neurons, localization of several distinct transmembrane proteins to dendrites is dependent on specific myosin motors and an intact actin network. Moreover, fusion with a myosin-binding domain

SUBMITTER: Lewis TL 

PROVIDER: S-EPMC2937175 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature