Relationship of injection drug use, antiretroviral therapy resistance, and genetic diversity in the HIV-1 pol gene.

ABSTRACT:

Objectives

To determine if a history of injection drug use influences genotypic protease inhibitor (PI) resistance to antiretroviral agents.

Methods

We assessed the presence of resistance mutations in PI-naive injection drug users (IDUs) and non-IDUs participating in the Women's Interagency HIV Study. Eighteen HIV-infected participants who reported injection drug use before study enrollment and 32 HIV-infected non-IDUs contributed a total of 34 and 65 person-visits, respectively, to analyses.

Results

Based on data from multiple clones obtained from different time points from each individual, we determined that primary PI resistance mutations were more frequent among person visits contributed by IDUs (24%) than non-IDUs (8%, P = 0.05). Although neither reached statisti

SUBMITTER: Kowalski J 

PROVIDER: S-EPMC2937199 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature