Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene.

ABSTRACT:

Rationale

Several family-based studies have identified genetic linkage for lung function and airflow obstruction to chromosome 2q.

Objectives

We hypothesized that merging results of high-resolution single nucleotide polymorphism (SNP) mapping in four separate populations would lead to the identification of chronic obstructive pulmonary disease (COPD) susceptibility genes on chromosome 2q.

Methods

Within the chromosome 2q linkage region, 2,843 SNPs were genotyped in 806 COPD cases and 779 control subjects from Norway, and 2,484 SNPs were genotyped in 309 patients with severe COPD from the National Emphysema Treatment Trial and 330 community control subjects. Significant associations from the combined results across the two case-control studies were followed up in 1,839

SUBMITTER: Hersh CP 

PROVIDER: S-EPMC2937234 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature