Activating transcription factor 3 confers protection against ventilator-induced lung injury.

ABSTRACT:

Rationale

Ventilator-induced lung injury (VILI) significantly contributes to mortality in patients with acute respiratory distress syndrome, the most severe form of acute lung injury. Understanding the molecular basis for response to cyclic stretch (CS) and its derangement during high-volume ventilation is of high priority.

Objectives

To identify specific molecular regulators involved in the development of VILI.

Methods

We undertook a comparative examination of cis-regulatory sequences involved in the coordinated expression of CS-responsive genes using microarray analysis. Analysis of stretched versus nonstretched cells identified significant enrichment for genes containing putative binding sites for the transcription factor activating transcription factor 3 (ATF3). T

SUBMITTER: Akram A 

PROVIDER: S-EPMC2937241 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature