Dietary interventions that lower lipoproteins containing apolipoprotein C-III are more effective in whites than in blacks: results of the OmniHeart trial.

ABSTRACT:

Background

Blacks have lower average triglyceride and LDL cholesterol concentrations than do whites but higher rates of coronary heart disease. Apolipoprotein (apo) C-III in VLDL and LDL stimulates atherogenic processes in vascular cells. In blacks, the concentration of lipoproteins with apo C-III is unknown, and the response to dietary strategies that lower triglyceride and apo C-III has not been investigated

Objective

We compared the concentration of and dietary effects on apo C-III-containing lipoproteins in blacks and whites.

Design

In a randomized, 3-period feeding study [OmniHeart (Optimal Macronutrient Intake Trial to Prevent Heart Disease)], we measured lipoprotein concentrations in 89 blacks and 73 whites who consumed self-selected diets (baseline) and after

SUBMITTER: Furtado JD 

PROVIDER: S-EPMC2937582 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature