Relation of maternal prepregnancy body mass index with offspring bone mass in childhood: is there evidence for an intrauterine effect?

ABSTRACT:

Background

Evidence indicates that intrauterine skeletal development has implications for bone mass in later life and that maternal fat stores in pregnancy are important for fetal bone mineral accrual.

Objective

We investigated whether childhood bone mass is influenced by maternal body mass index (BMI) via an intrauterine mechanism by comparing parental associations.

Design

We conducted a multivariable regression analysis of 7121 children in the Avon Longitudinal Study of Parents and Children. Total body less head (TBLH) and spine bone measures were derived from dual-energy X-ray absorptiometry scans at a mean age of 9.9 y. Maternal and paternal BMI values were derived from self-reported weight and height during pregnancy.

Results

Maternal prepregnancy BMI (SD

SUBMITTER: Macdonald-Wallis C 

PROVIDER: S-EPMC2937586 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature