Genogroup IIb norovirus infections and association with enteric symptoms in a neonatal nursery in southern India.

ABSTRACT: Noroviruses (NoVs) are increasingly recognized as an important cause of acute gastroenteritis in children worldwide. However, there are limited data on the role of NoVs in neonatal infections and disease. The objectives of the present study were to determine the prevalence of NoVs in neonates with gastrointestinal disease using a case-control study design and to characterize the NoV strains infecting neonates. A total of 309 fecal samples from 161 neonates with gastrointestinal symptoms and 148 asymptomatic controls were screened for genogroup II (GII) NoV using reverse transcription-PCR. A subset of PCR-positive amplicons for the polymerase and capsid regions was sequenced. NoV was detected in 26.2% of samples, with the rate of detection being significantly higher among symptomatic neonat

SUBMITTER: Menon VK 

PROVIDER: S-EPMC2937701 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature