Molecular epidemiological evaluation of the recent resurgence in mumps virus infections in Ireland.

ABSTRACT: Mumps is a vaccine-preventable disease; however, outbreaks have been reported in a number of countries with childhood immunization programs, particularly among young adults at the tertiary stage of education. We have retrospectively investigated the epidemiological, virological, and serological factors associated with mumps cases identified in Ireland from 2004 to 2009. Genetic analysis of mumps virus strain variability demonstrated that a single genotype, genotype G, was circulating, and it was also detected in cerebrospinal fluid samples obtained from patients with meningitis. We observed that younger individuals were disproportionately affected with neurological sequelae following mumps virus infection, and the average age of patients with mumps virus RNA detected in cerebrospinal fluid

SUBMITTER: Carr MJ 

PROVIDER: S-EPMC2937737 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature