Building macromolecular assemblies by information-driven docking: introducing the HADDOCK multibody docking server.

ABSTRACT: Over the last years, large scale proteomics studies have generated a wealth of information of biomolecular complexes. Adding the structural dimension to the resulting interactomes represents a major challenge that classical structural experimental methods alone will have difficulties to confront. To meet this challenge, complementary modeling techniques such as docking are thus needed. Among the current docking methods, HADDOCK (High Ambiguity-Driven DOCKing) distinguishes itself from others by the use of experimental and/or bioinformatics data to drive the modeling process and has shown a strong performance in the critical assessment of prediction of interactions (CAPRI), a blind experiment for the prediction of interactions. Although most docking programs are limited to binary complexes,

SUBMITTER: Karaca E 

PROVIDER: S-EPMC2938057 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature