Identification of quantitative trait loci underlying proteome variation in human lymphoblastoid cells.

ABSTRACT: Population-based variability in protein expression patterns, especially in humans, is often observed but poorly understood. Moreover, very little is known about how interindividual genetic variation contributes to protein expression patterns. To begin to address this, we describe elements of technical and biological variations contributing to expression of 544 proteins in a population of 24 individual human lymphoblastoid cell lines that have been extensively genotyped as part of the International HapMap Project. We determined that expression levels of 10% of the proteins were tightly correlated to cell doubling rates. Using the publicly available genotypes for these lymphoblastoid cell lines, we applied a genetic association approach to identify quantitative trait loci associated with pro

SUBMITTER: Garge N 

PROVIDER: S-EPMC2938086 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature