Quantitative proteomics and metabolomics analysis of normal human cerebrospinal fluid samples.

ABSTRACT: The analysis of cerebrospinal fluid (CSF) is used in biomarker discovery studies for various neurodegenerative central nervous system (CNS) disorders. However, little is known about variation of CSF proteins and metabolites between patients without neurological disorders. A baseline for a large number of CSF compounds appears to be lacking. To analyze the variation in CSF protein and metabolite abundances in a number of well-defined individual samples of patients undergoing routine, non-neurological surgical procedures, we determined the variation of various proteins and metabolites by multiple analytical platforms. A total of 126 common proteins were assessed for biological variations between individuals by ESI-Orbitrap. A large spread in inter-individual variation was observed (relative

SUBMITTER: Stoop MP 

PROVIDER: S-EPMC2938111 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature