Identification of genes and pathways associated with cytotoxic T lymphocyte infiltration of serous ovarian cancer.

ABSTRACT:

Background

Tumour-infiltrating lymphocytes (TILs) are predictors of disease-specific survival (DSS) in ovarian cancer. It is largely unknown what factors contribute to lymphocyte recruitment. Our aim was to evaluate genes and pathways contributing to infiltration of cytotoxic T lymphocytes (CTLs) in advanced-stage serous ovarian cancer.

Methods

For this study global gene expression was compared between low TIL (n=25) and high TIL tumours (n=24). The differences in gene expression were evaluated using parametric T-testing. Selectively enriched biological pathways were identified with gene set enrichment analysis. Prognostic influence was validated in 157 late-stage serous ovarian cancer patients. Using immunohistochemistry, association of selected genes from identified pathwa

SUBMITTER: Leffers N 

PROVIDER: S-EPMC2938262 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature