A unified 35-gene signature for both subtype classification and survival prediction in diffuse large B-cell lymphomas.

ABSTRACT: Cancer subtype classification and survival prediction both relate directly to patients' specific treatment plans, making them fundamental medical issues. Although the two factors are interrelated learning problems, most studies tackle each separately. In this paper, expression levels of genes are used for both cancer subtype classification and survival prediction. We considered 350 diffuse large B-cell lymphoma (DLBCL) subjects, taken from four groups of patients (activated B-cell-like subtype dead, activated B-cell-like subtype alive, germinal center B-cell-like subtype dead, and germinal center B-cell-like subtype alive). As classification features, we used 11,271 gene expression levels of each subject. The features were first ranked by mRMR (Maximum Relevance Minimum Redundancy) princip

SUBMITTER: Cai YD 

PROVIDER: S-EPMC2938343 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature