Estimating the impact of plasma HIV-1 RNA reductions on heterosexual HIV-1 transmission risk.

ABSTRACT:

Background

The risk of sexual transmission of HIV-1 is strongly associated with the level of HIV-1 RNA in plasma making reduction in HIV-1 plasma levels an important target for HIV-1 prevention interventions. A quantitative understanding of the relationship of plasma HIV-1 RNA and HIV-1 transmission risk could help predict the impact of candidate HIV-1 prevention interventions that operate by reducing plasma HIV-1 levels, such as antiretroviral therapy (ART), therapeutic vaccines, and other non-ART interventions.

Methodology/principal findings

We use prospective data collected from 2004 to 2008 in East and Southern African HIV-1 serodiscordant couples to model the relationship of plasma HIV-1 RNA levels and heterosexual transmission risk with confirmation of HIV-1 transmissi

SUBMITTER: Lingappa JR 

PROVIDER: S-EPMC2938354 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature