Variation in the gene TAS2R38 is associated with the eating behavior disinhibition in Old Order Amish women.

ABSTRACT: Insensitivity to the bitter-tasting compound 6-n-propylthiouracil (PROP) has been proposed as a marker for individual differences in taste perception that influence food preference and intake. The principal genetic determinants of phenotypic variation in PROP taste sensitivity are alleles of the TAS2R38 gene, which encodes a chemosensory receptor sensitive to thiourea compounds including PROP and phenylthiocarbamide. Members of the TAS2R family are expressed in the gustatory system, where they function as bitter taste receptors, and throughout the gut, where their physiological roles in prandial, gut-derived hormone release are beginning to be elucidated. To better understand the relationship between TAS2R function and ingestive behaviors, we asked if TAS2R38 variants are associated with o

SUBMITTER: Dotson CD 

PROVIDER: S-EPMC2938875 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature