TNFRSF11A and TNFSF11 are associated with age at menarche and natural menopause in white women.

ABSTRACT:

Objective

Menarche and menopause mark the lower and upper limits of the female reproductive period. The timing of these events influences women's health in later life. The onsets of menarche and menopause have a strong genetic basis. We tested two genes, TNFRSF11A (RANK) and TNFSF11 (RANKL), for their association with age at menarche (AM) and age at natural menopause (ANM).

Methods

Nineteen single nucleotide polymorphisms (SNPs) of TNFRSF11A and 12 SNPs of TNFSF11 were genotyped in a random sample of 306 unrelated white women. This sample was analyzed for the association of the SNPs and common haplotypes with AM. Then, a subsample of 211 women with natural menopause was analyzed for the association of both genes with ANM. Smoking, alcohol intake, and duration of lactation we

SUBMITTER: Lu Y 

PROVIDER: S-EPMC2939156 | biostudies-literature | 2010 Sep-Oct

REPOSITORIES: biostudies-literature