L1CAM expression in endometrial carcinomas is regulated by usage of two different promoter regions.

ABSTRACT:

Background

The L1 cell adhesion molecule (L1CAM) was originally identified as a neural adhesion molecule involved in axon guidance. In many human epithelial carcinomas L1CAM is overexpressed and thereby augments cell motility, invasion and metastasis formation. L1CAM positive carcinomas are associated with bad prognosis. Recent data point out that L1CAM is regulated in a fashion similar to epithelial-mesenchymal transition (EMT). Previous studies have implied the transcription factors Slug and/or β-catenin in L1CAM transcriptional regulation. However, the regulation of human L1CAM expression at the transcriptional level is not well understood.

Results

To better understand the molecular basis of L1CAM transcriptional regulation, we carried out a detailed characterization of t

SUBMITTER: Pfeifer M 

PROVIDER: S-EPMC2939505 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature