Computational simulation of vasopressin secretion using a rat model of the water and electrolyte homeostasis.

ABSTRACT:

Background

In mammals, vasopressin (AVP) is released from magnocellular neurons of the hypothalamus when osmotic pressure exceeds a fixed set-point. AVP participates to the hydromineral homeostasis (HH) by controlling water excretion at the level of the kidneys. Our current understanding of the HH and AVP secretion is the result of a vast amount of data collected over the five past decades. This experimental data was collected using a number of systems under different conditions, giving a fragmented view of the components involved in HH.

Results

Here, we present a high-level model of the rat HH based on selected published results to predict short-term (hours) to long-term (days) variation of six major homeostatic parameters: (1) the extracellular sodium concentration, (2) th

SUBMITTER: Nadeau L 

PROVIDER: S-EPMC2939538 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature