Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation.

ABSTRACT:

Background

Pax2;5;8 transcription factors play diverse roles in vertebrate and invertebrate organogenesis, including the development of the inner ear. Past research has suggested various cochlear defects and some vestibular defects in Pax2 null mice but the details of the cochlear defects and the interaction with other Pax family members in ear development remain unclear.

Results

We show that Pax2;8 double null mice do not develop an ear past the otocyst stage and show little to no sensory as well as limited and transient neuronal development, thus indicating that these two family members are essential for overall ear morphogenesis and sustained neurosensory development. In support of functional redundancy between Pax proteins, Pax2 can be substituted by a Pax5 minigene, a g

SUBMITTER: Bouchard M 

PROVIDER: S-EPMC2939565 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature