Effect of tryptophan hydroxylase-2 rs7305115 SNP on suicide attempts risk in major depression.

ABSTRACT:

Background

Suicide and major depressive disorders (MDD) are strongly associated, and genetic factors are responsible for at least part of the variability in suicide risk. We investigated whether variation at the tryptophan hydroxylase-2 (TPH2) gene rs7305115 SNP may predispose to suicide attempts in MDD.

Methods

We genotyped TPH2 gene rs7305115 SNP in 215 MDD patients with suicide and matched MDD patients without suicide. Differences in behavioral and personality traits according to genotypic variation were investigated by logistic regression analysis.

Results

There were no significant differences between MDD patients with suicide and controls in genotypic (AG and GG) frequencies for rs7305115 SNP, but the distribution of AA genotype differed significantly (14.4% vs.

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC2939585 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature