Dataset Information

Effect of tryptophan hydroxylase-2 rs7305115 SNP on suicide attempts risk in major depression.

ABSTRACT:

Background

Suicide and major depressive disorders (MDD) are strongly associated, and genetic factors are responsible for at least part of the variability in suicide risk. We investigated whether variation at the tryptophan hydroxylase-2 (TPH2) gene rs7305115 SNP may predispose to suicide attempts in MDD.

Methods

We genotyped TPH2 gene rs7305115 SNP in 215 MDD patients with suicide and matched MDD patients without suicide. Differences in behavioral and personality traits according to genotypic variation were investigated by logistic regression analysis.

Results

There were no significant differences between MDD patients with suicide and controls in genotypic (AG and GG) frequencies for rs7305115 SNP, but the distribution of AA genotype differed significantly (14.4% vs. 29.3%, p < 0.001). The G-allele frequency was significantly higher in cases than control group (58.1% vs.45.6%, p < 0.001), but the A-allele carrier indicated a decreased trend in MDD with suicide behaviors than control group (41.9% vs.54.4%, p < 0.001). The multivariate logistic regression analysis indicated that TPH2 rs7305115 AA (OR 0.33, 95% CI 0.22-0.99), family history of suicide (OR 2.98, 95% CI 1.17-5.04), negative life events half year ago (OR 6.64, 95% CI 2.48-11.04) and hopelessness (OR 7.68, 95% CI 5.79-13.74) were significantly associated with the suicide behaviors in MDD patients.

Conclusions

The study suggested that hopelessness, negative life events and family history of suicide were risk factors of attempted suicide in MDD while the TPH2 rs7305115A remained a significant protective predictor of suicide attempts.

SUBMITTER: Zhang Y

PROVIDER: S-EPMC2939585 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Effect of tryptophan hydroxylase-2 rs7305115 SNP on suicide attempts risk in major depression.

Zhang Yuqi Y Zhang Changsong C Yuan Guozhen G Yao Jianjun J Cheng Zaohuo Z Liu Chaojun C Liu Qinghai Q Wan Gairong G Shi Guizhi G Cheng Yiren Y Ling Yang Y Li Ke K

Behavioral and brain functions : BBF 20100825

<h4>Background</h4>Suicide and major depressive disorders (MDD) are strongly associated, and genetic factors are responsible for at least part of the variability in suicide risk. We investigated whether variation at the tryptophan hydroxylase-2 (TPH2) gene rs7305115 SNP may predispose to suicide attempts in MDD.<h4>Methods</h4>We genotyped TPH2 gene rs7305115 SNP in 215 MDD patients with suicide and matched MDD patients without suicide. Differences in behavioral and personality traits according ...[more]

PMID: 20738857

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Dataset Information

Effect of tryptophan hydroxylase-2 rs7305115 SNP on suicide attempts risk in major depression.

Background

Methods

Results

Conclusions

Publications

Effect of tryptophan hydroxylase-2 rs7305115 SNP on suicide attempts risk in major depression.

Similar Datasets

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