Modeling dose-response relationships of the effects of fesoterodine in patients with overactive bladder.

ABSTRACT:

Background

Fesoterodine is an antimuscarinic for the treatment of overactive bladder, a syndrome of urgency, with or without urgency urinary incontinence (UUI), usually with increased daytime frequency and nocturia. Our objective was to develop predictive models to describe the dose response of fesoterodine.

Methods

Data from subjects enrolled in double-blind, placebo-controlled phase II and III trials were used for developing longitudinal dose-response models.

Results

The models predicted that clinically significant and near-maximum treatment effects would be seen within 3 to 4 weeks after treatment initiation. For a typical patient with 11 micturitions per 24 hours at baseline, predicted change was -1.2, -1.7, and -2.2 micturitions for placebo and fesoterodine 4 mg

SUBMITTER: Cardozo L 

PROVIDER: S-EPMC2939595 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature