Forward-time simulation of realistic samples for genome-wide association studies.

ABSTRACT:

Background

Forward-time simulations have unique advantages in power and flexibility for the simulation of genetic samples of complex human diseases because they can closely mimic the evolution of human populations carrying these diseases. However, a number of methodological and computational constraints have prevented the power of this simulation method from being fully explored in existing forward-time simulation methods.

Results

Using a general-purpose forward-time population genetics simulation environment, we developed a forward-time simulation method that can be used to simulate realistic samples for genome-wide association studies. We examined the properties of this simulation method by comparing simulated samples with real data and demonstrated its wide applicability

SUBMITTER: Peng B 

PROVIDER: S-EPMC2939614 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature