Increased mortality in HER2 positive, oestrogen receptor positive invasive breast cancer: a population-based study.

ABSTRACT:

Background

This study assessed the impact of human epidermal growth factor receptor 2 (HER2) status on the outcomes in an unselected population of breast cancer patients who did not receive HER2-targeted therapy.

Methods

HER2 status by immunohistochemistry and fluorescence in situ hybridisation was compared with clinicopathological data, overall survival (OS) and disease-free survival (DFS) for all patients presenting with breast cancer over 3 years.

Results

In 865 patients (median follow up 6.02 years), HER2 positivity was identified in 13.3% of all cancers and was associated with higher tumour grade (P<10(-8)), lymphovascular invasion (P<0.001) and axillary nodal metastasis (P=0.003). There was a negative association with oestrogen-receptor (ER) and progesterone-rec

SUBMITTER: Purdie CA 

PROVIDER: S-EPMC2939790 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature