New views on strand asymmetry in insect mitochondrial genomes.

ABSTRACT: Strand asymmetry in nucleotide composition is a remarkable feature of animal mitochondrial genomes. Understanding the mutation processes that shape strand asymmetry is essential for comprehensive knowledge of genome evolution, demographical population history and accurate phylogenetic inference. Previous studies found that the relative contributions of different substitution types to strand asymmetry are associated with replication alone or both replication and transcription. However, the relative contributions of replication and transcription to strand asymmetry remain unclear. Here we conducted a broad survey of strand asymmetry across 120 insect mitochondrial genomes, with special reference to the correlation between the signs of skew values and replication orientation/gene direction. T

SUBMITTER: Wei SJ 

PROVIDER: S-EPMC2939890 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature