Evaluating diagnostic accuracy of genetic profiles in affected offspring families.

ABSTRACT: Diagnostic accuracy of a genetic test involving multiple disease genes is evaluated using sensitivity and specificity. For estimation, data from both affected and unaffected subjects are required. For early onset diseases, such as autism spectrum disorder (ASD), only data from families with affected offspring are available. To enable estimation of specificity when no data for unaffected offspring are available (single affected offspring, SAO, data), we combine the pseudocontrol method of Cordell and Clayton (Am. J. Hum. Genet. 2002; 70:124-141) with the approach of DeLong et al. (Biometrics 1985; 41:947-958) in a logistic regression model for disease outcome with a risk score (RS) constructed from genotype information as prognostic variable. The area under the receiver operating characteri

SUBMITTER: Carayol J 

PROVIDER: S-EPMC2939926 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature