Striatal regulation of ΔFosB, FosB, and cFos during cocaine self-administration and withdrawal.

ABSTRACT: Chronic drug exposure induces alterations in gene expression profiles that are thought to underlie the development of drug addiction. The present study examined regulation of the Fos-family of transcription factors, specifically cFos, FosB, and ΔFosB, in striatal subregions during and after chronic intravenous cocaine administration in self-administering and yoked rats. We found that cFos, FosB, and ΔFosB exhibit regionally and temporally distinct expression patterns, with greater accumulation of ΔFosB protein in the nucleus accumbens (NAc) shell and core after chronic cocaine administration, whereas ΔFosB increases in the caudate-putamen (CPu) remained similar with either acute or chronic administration. In contrast, tolerance developed to cocaine-induced mRNA for ΔFosB in all three stria

SUBMITTER: Larson EB 

PROVIDER: S-EPMC2939959 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature