Ontology highlight
ABSTRACT:
SUBMITTER: Itoh T
PROVIDER: S-EPMC2939985 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20080901 9
The nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) has important roles in adipogenesis and immune response as well as roles in both lipid and carbohydrate metabolism. Although synthetic agonists for PPARgamma are widely used as insulin sensitizers, the identity of the natural ligand(s) for PPARgamma is still not clear. Suggested natural ligands include 15-deoxy-delta12,14-prostaglandin J2 and oxidized fatty acids such as 9-HODE and 13-HODE. Crystal structures of PP ...[more]